@article {45605,
	title = {Telescoped sequence of exothermic and endothermic reactions in multistep flow synthesis},
	journal = {Organic Process Research and Development},
	year = {2019},
	month = {JAN},
	pages = {Article ASAP},
	type = {Article},
	abstract = {A multistep sequential flow synthesis of isopropyl phenol is demonstrated, involving 4-step exothermic, endothermic, and temperature sensitive reactions such as nitration, reduction, diazotization, and high temperature hydrolysis. Nitration of cumene with fuming nitric acid produces 2- and 4-nitrocumene which are converted into respective cumidines by the hydrogenation using Pd/Ni catalyst in H-cube with gravity separation. Hydrolysis of in situ generated diazonium salts in the boiling acidic conditions is carried out using integration of flow and microwave-assisted synthesis. 58\% of 4-isopropyl phenol was obtained. The sequential flow synthesis can be applied to synthesize other organic compounds involving this specific sequence of reactions.},
	doi = {10.1021/acs.oprd.8b00008},
	author = {Sharma, Y. and Nikam, A. V. and Kulkarni, A. A.}
}
