@article {45550,
	title = {Scalable synthesis of both enantiomers of vigabatrin, an antiepileptic drug},
	journal = {European Journal of Organic Chemistry},
	year = {2019},
	month = {FEB},
	pages = {1257{\textendash}1260},
	type = {Article},
	abstract = {<p>Vigabatrin is a potent inhibitor of gamma-aminobutyric acid (GABA) catabolism used for the treatment of epilepsy. Here we have synthesized both enantiomers of the drug vigabatrin in five steps from known intermediates using Wittig olefination and pyrolytic elimination as key steps. The target compounds are synthesized in gram scale amounts with \&gt;98 \% enantiopurity.</p>
},
	doi = {10.1002/ejoc.201801617},
	author = {Jachak, G.R. and Reddy, D.S.}
}
