@article {45438,
	title = {Ruthenium-catalyzed regioselective alkenylation/tandem hydroamidative cyclization of unmasked quinazolinones using terminal alkynes},
	journal = {Journal of Organic Chemistry},
	volume = {83},
	year = {2018},
	month = {AUG},
	pages = {8906-8913},
	type = {Article},
	abstract = {<p>Ruthenium-catalyzed amide directed C-sp2-H activation of the quinazolinone scaffold has been demonstrated, leading to the selective mono- or dialkenylation in moderate to good yields to achieve medicinally important stilbene containing quinazolinones. The terminal allcyne is utilized as a coupling partner, which resulted in the selective trans-alkene formation. Electron-deficient phenylacetylenes facilitate alkenylation followed by tandem hydroamidation of the newly generated trans double bond to provide novel quinazolinone alkaloids related to the Luotonine class of natural products.</p>},
	doi = {10.1021/acs.joc.8b01143},
	author = {Viveki, Amol B. and Mhaske, Santosh B.}
}
