@article {45396,
	title = { Nickel-catalyzed regioselective C(2)-H difluoroalkylation of indoles with difluoroalkyl bromides},
	journal = {Chemistry-An Asian Journal},
	volume = {13},
	year = {2018},
	month = {SEP},
	pages = {2516-2521},
	type = {Article},
	abstract = {Regioselective C(2)-H difluoroalkylation of C-3 unsubstituted indoles with commonly available fluoroalkyl bromides is successfully achieved employing a simple nickel catalyst system, (DME)NiCl2/Xantphos. This methodology shows excellent regioselectivity and exhibits a broad substrate scope. Various functional groups, such as -OMe, -F, and -Br, are tolerated on the indole backbone to give the difluoroalkylated products in moderate to good yields. Preliminary mechanistic findings demonstrate that the reaction is homogeneous in nature and involves a radical manifold. Synthetic utility of this nickel-catalyzed method is demonstrated by synthesizing melatonin receptor antagonist Luzindole derivative.},
	doi = {10.1002/asia.201800504},
	author = {Soni, Vineeta and Sharma, Dipesh M. and Punji, Benudhar}
}
