@article {44627,
	title = {Copper- and phosphine-free nickel(II)-catalyzed method for C-H bond alkynylation of benzothiazoles and related azoles},
	journal = {Asian Journal of Organic Chemistry},
	volume = {7},
	year = {2018},
	month = {JUL},
	pages = {1390-1395},
	abstract = {<p>A phosphine-free nickel(II)-catalyzed method for the C(2)-H bond alkynylation of (benzo)thiazoles, (benz)imidazoles, and oxazoles is described. Well-defined and air-stable (Phen)NiCl2 catalyst efficiently catalyzes the coupling of diverse azoles with alkynyl bromides without the use of a copper co-catalyst, and the method tolerates synthetically important functional groups. Preliminary mechanistic studies on this Ni-II-catalyzed alkynylation emphasize the homogeneous nature of the catalyst, and rule out a radical manifold for the reaction. The synthetic utility of this Ni-catalyzed method is demonstrated by further functionalizing the alkynylated benzothiazoles to 3-methyl-2-(alkynyl)benzo[d]thiazolium salts that are known DNA cleaving agents.</p>},
	keywords = {alkynylation, azoles, C-H activation, heterocycles, Nickel},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201800243},
	author = {Patel, Ulhas N. and Punji, Benudhar}
}
