@article {44507,
	title = {Synthesis of 4-difluoromethylquinolines by NHC-catalyzed umpolung of imines},
	journal = { Organic Letters},
	volume = {20},
	year = {2018},
	month = {JAN},
	pages = {1086{\textendash}1089},
	type = {Journal Article},
	abstract = {The N-heterocyclic carbene (NHC)-catalyzed umpolung of aldimines for the synthesis of 4-difluoromethylquinoline derivatives is reported. In the presence of NHCs, the intramolecular cyclization of aldimines bearing a moderately electron-poor double bond due to the presence of the -CF3 group likely proceeds via the intermediacy of the aza-Breslow intermediate. The key to the success of this aza-Stetter type transformation is the NHC generated from the bicyclic triazolium salt using DBU as the base.},
	issn = {15237060},
	doi = {10.1021/acs.orglett.7b04055},
	author = {Patra, Atanu},
	editor = {Gelat, Fabien}
}
