@article {44210,
	title = {X-ray crystal structures and anti-breast cancer property of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acids},
	journal = {New Journal of Chemistry},
	volume = {42},
	year = {2018},
	month = {JAN},
	pages = {1078-1086},
	type = {Article},
	abstract = {<p>Diastereomeric {\textquoteleft}2RS, 4R{\textquoteright}-2-arylthiazolidine-4-carboxylic acids (ATCAs) were synthesized and their resolution to chiraly pure N-BOC derivatives was attempted by column chromatography. The absolute stereochemistry of the resolved compounds was ascertained by X-ray single crystal structures. Further application of the synthesized compounds was studied for their in vitro anti-breast cancer activity against MCF7 cell line using DOX as a standard by MTT assay method. Cell morphology analysis was carried out by fluorescence microscopy. The compounds containing {\textquoteleft}2S{\textquoteright} absolute configuration in thiazolidine ring and presence of 2-NO2, 2,6-Cl groups on {\textquoteleft}2R{\textquoteright}-aryl substituent showed significant antibreast cancer activity where some of the compounds were found to be more active than DOX in terms of induced apoptosis mode of MCF7 cell death.</p>},
	issn = {1144-0546},
	doi = {10.1039/c7nj02961f},
	author = {Jagtap, Rohidas M. and Thorat, Shridhar H. and Gonnade, Rajesh G. and Khan, Ayesha A. and Pardeshi, Satish K.}
}
