@article {44151,
	title = {Total synthesis of (+/-)/(+)-subincanadine E and determination of absolute configuration},
	journal = {Journal of Organic Chemistry},
	volume = {82},
	year = {2017},
	month = {OCT},
	pages = {11126-11133},
	type = {Article},
	abstract = {A facile synthesis of (+/-)-subincanadine E was described from tryptamine-based maleimide. 1,2-Addition of Grignard reagent to maleimide, internal activation of formed lactamol for in situ 1,4-addition of Grignard reagent, and associated position-specific allylic rearrangement in diastereoselective Pictet-Spengler cyclization were the key steps. Enantioselective first total synthesis of naturally occurring cytotoxic (+)-subincanadine E was also accomplished from (S)-acetoxysuccinimide via an unusual syn-addition of cuprate to the alpha/beta-unsaturated lactam. Sinister absolute configuration was assigned to (+)-subincanadine E on the basis of total synthesis. (S)-Acetoxy group in the succinimide precursor was initially employed to impart regio- and stereoselectivity and then as a suitable leaving group to generate the desired conjugated lactam.},
	doi = {10.1021/acs.job.7b02122},
	author = {Kalshetti, Manojkumar G. and N. P. Argade}
}
