@article {43725,
	title = {Rigid peptide scaffold-incorporated structural analogs of the potent antidepressant peptide drug rapastinel (GLYX-13)},
	journal = {Chemistryselect},
	volume = {2},
	year = {2017},
	month = {APR},
	pages = {3594-3596},
	type = {Article},
	abstract = {<p>Rapastinel (GLYX-13) is a natural amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2)endowed with strong antidepressant property. Rapastinel shows considerable promise for treating drug-resistant major depressive disorder (MDD), and is under clinical phase III development. Herein, we report the synthesis of a novel class of analogues of the potent antidepressant peptide drug rapastinel featuring rigid dipeptide scaffolds comprising proline (L/D) and amino thiophene carboxylates (Atc). Amino thiophene carboxylate is a conformationally constrained aromatic beta-amino acid, known to rigidify peptide backbones thereby limiting the conformational flexibility of peptides and improving proteolytic stability.</p>},
	doi = {10.1002/slct.201700605},
	author = {Nadimpally, Krishna Chaitanya and Chakrapani, Aswathi and Prabhu, Priyanka J. and Madica, Krishnaprasad and Sanjayan, Gangadhar J.}
}
