@article {43603,
	title = {Cascade synthesis of 2-cyanoacrylamides through deacetalization and/or knoevenagelcondensation followed by selective monohydration of acetals and aldehydes over solid acidferrites},
	journal = {Chemcatchem},
	volume = {8},
	year = {2016},
	month = {AUG},
	pages = {2678-2687},
	abstract = {A new protocol of cascade synthesis for biologically active 2-cyanoacrylamides (1) was developed. The reaction proceeds over a novel magnetically retrievable solid-acid composite of iron oxide, poly(vinylpyrrolidone) and phosphotungstic acid (Fe3O4/PVP-PWA) in AcOH-H2O medium under reflux conditions. This transformation is facilitated through single-site Bronsted acid catalyzed cascade reactions involving deacetalization and/or Knoevenagel condensation followed by selective monohydration of nitriles starting from acetals (5) and aldehydes (2) with malononitrile (3). A series of aldehydes, dimethyl and diethyl acetals, along with some heterocyclic aldehydes were successfully transformed to 2-cyanoacrylamides with >95\% yields. TEM images confirmed the coating of the PVP over nanosized Fe3O4. Stereoselective monohydration of 2-benzylidenemalononitriles (4) to E isomers was demonstrated by NOESY experiments. The catalyst could be efficiently recycled seven times on employment of both acetals and aldehydes as substrates, as a result of its magnetic nature.},
	doi = {10.1002/cctc.201600426},
	author = {Kamble, Sumit B. and Rode, Chandrashekhar V.}
}
