@article {43461,
	title = {Iron complex catalyzed selective C-H bond oxidation with broad substrate scope},
	journal = {Organic Letters},
	volume = {19},
	year = {2017},
	month = {FEB},
	pages = {746-749},
	abstract = {<p>The use of a peroxidase-mimicking Fe complex has been reported on the basis of the biuret-modified TAML macrocyclic ligand {\textquoteright}framework (Fe-bTAML) as a catalyst to perform selective oxidation of unactivated 3 degrees C-H bonds and activated 2 degrees C-H bonds with low catalyst loading (1 mol \%) and high product yield (excellent mass balance) under near neutral conditions and broad substrate scope (18 substrates which includes arenes, heteroaromatics, and polar functional groups). Aliphatic C-H oxidation of 3 and 2 sites of complex substrates was achieved with predictable selectivity using steric, electronic, and stereoelectronic rules that govern site selectivity, which included oxidation of (+)-artemisinin to (+)-10 beta-hydroxyartemisinin. Mechanistic studies indicate Fe-V(O) to be the active oxidant during these reactions.</p>},
	doi = {10.1021/acs.orglett.6b03359},
	author = {Jana, Sandipan and Ghosh, Munmun and Ambule, Mayur and Sen Gupta, Sayam}
}
