@article {42738,
	title = {Unified strategy for nickel-catalyzed C-2 Alkylation of indoles through chelation assistance},
	journal = {ACS Catalysis},
	volume = {6},
	year = {2016},
	month = {JUL},
	pages = {5666{\textendash}5672},
	abstract = {<p>A nickel-catalyzed direct C-2 alkylation of indoles through monodentate-chelation assistance has been described. This reaction proceeds via an unusual strategy by the use of a well-designed and defined (quinolinyl)amido{\textendash}nickel catalyst, [{κN,κN,κN-Et2NCH2C(O)(μ-N)C9H6N}Ni(OAc)], providing a solution to the limitations associated with bidentate-chelate auxiliaries. The method allows coupling of indoles with various unactivated primary and secondary alkyl halides with ample substrate scope. This uniquely strategized alkylation proceeded through crucial C{\textendash}H activation and via an alkyl radical intermediate. The reaction by this approach represents a rare example of Ni-catalyzed monodentate-chelate-assisted C{\textendash}H functionalization.</p>},
	doi = {10.1021/acscatal.6b02003},
	author = {Soni, Vineeta and Jagtap, Rahul A. and Gonnade, Rajesh G. and Punji, Benudhar}
}
