@article {42631,
	title = {Crystal engineering of a zwitterionic drug to neutral cocrystals: a general solution for floxacins},
	journal = {Chemical Communications},
	volume = {52},
	year = {2016},
	month = {SEP},
	pages = {12610-12613},
	abstract = {<p>The transformation of zwitterionic Sparfloxacin (SPX) to the neutral form is achieved by cocrystallization. Neutral forms of drugs are important for higher membrane permeability, while zwitterions are more soluble in water. The twin advantages of higher solubility/dissolution rate and good stability of neutral SPX are achieved in a molecular cocrystal compared to its zwitterionic SPX hydrate. The amine-phenol supra-molecular synthon drives cocrystal formation, with the paraben ester acting as a "proton migrator{\textquoteright}{\textquoteright} for the ionic to neutral transformation.</p>},
	doi = {10.1039/c6cc06627e},
	author = {Gunnam, Anilkumar and Suresh, Kuthuru and Ganduri, Ramesh and Nangia, Ashwini}
}
