@article {42521,
	title = {Photoactive RuII-polypyridyl complexes that display sequence selectivity and high-affinity binding to duplex DNA through groove binding},
	journal = {Chemistry A European Journal},
	volume = {17},
	year = {2011},
	month = {FEB},
	pages = {2089{\textendash}2098},
	abstract = {<p>The duplex-DNA binding properties of a nonintercalating polypyridyl ruthenium(II) complex that incorporates a linear extended ligand with a catechol moiety has been probed with a variety of photo- and biophysical techniques. These studies reveal that the complex groove binds to DNA sequences biphasically, and displays binding constants equivalent to those of high-affinity metallointercalators. The complex also displays preferential binding to AT-rich sequences. Changes in the structure of the coordinated catechol ligand and the incorporation of intercalating ancillary ligands into the complex were found to modulate both the optical-binding response and binding parameters of the system, which indicates that the catechol moiety plays a crucial role in the observed enhancement to binding affinities.</p>},
	doi = {10.1002/chem.201002149},
	author = {Ghosh, Amrita and Das, Priyadip and Gill, Martin R. and Kar, Prasenjit and Walkar, Michael G. and Thomas, Jim A. and Das, Amitava}
}
