@article { ISI:000374811300057,
	title = {Shape and size engineered cellulosic nanomaterials as broad spectrum anti-microbial compounds},
	journal = {International Journal of Biological Macromolecules},
	volume = {87},
	year = {2016},
	month = {JUN},
	pages = {460-465},
	publisher = {ELSEVIER SCIENCE BV},
	address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS},
	abstract = {<p>Oxidized celluloses have been used for decades as antimicrobial wound gauzes and surgical cotton. We now report the successful synthesis of a next generation narrow size range (25-35 nm) spherical shaped nanoparticles of 2,3,6-tricarboxycellulose based on cellulose I structural features, for applications as new antimicrobial materials. This study adds to our previous study of 6-carboxycellulose. A wide range of bacteria such as Escherichia coli, Staphloccocus aureus, Bacillus subtilis and Mycobacterium tuberculosis (non-pathogenic as well as pathogenic strains) were affected by these polymers in in vitro studies. Activity against Mycobacteria were noted at high concentrations (MIC99 values 250-1000 mu g/ml, as compared to anti-TB drug Isoniazid 0.3 mu g/ml). However, the broad spectrum activity of oxidized celluloses and their nanoparticles against a wide range of bacteria, including Mycobacteria, show that these materials are promising new biocompatible and biodegradable drug delivery vehicles wherein they can play the dual role of being a drug encapsulant as well as a broad spectrum anti-microbial and anti-TB drug. (C) 2016 Published by Elsevier B.V.</p>},
	keywords = {Anti-microbial, cellulose, Spherical nanoparticles, Tricarboxycellulose},
	issn = {0141-8130},
	doi = {10.1016/j.ijbiomac.2016.02.024},
	author = {Sharma, Priyanka R. and Kamble, Sunil and Sarkar, Dhiman and Anand, Amitesh and Varma, Anjanikumar}
}
