@article { ISI:000238312300038,
	title = {Facile synthesis of 1,3,7-trihydroxyxanthone and its regioselective coupling reactions with prenal: simple and efficient access to osajaxanthone and nigrolineaxanthone F},
	journal = {Journal of Organic Chemistry},
	volume = {71},
	number = {13},
	year = {2006},
	month = {JUN},
	pages = {4992-4995},
	publisher = {AMER CHEMICAL SOC},
	type = {Article},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>A facile five-step synthesis of naturally occurring 1,3,7-trihydroxyxanthone has been described starting from 1,3,5-trimethoxybenzene via NBS-induced nuclear bromination, lithiation followed by an in situ benzoylation with methyl 2,5-dibenzyloxybenzoate, selective deprotection of the two benzyl groups, base-catalyzed intramolecular cyclization, and demethylations pathway with 62\% overall yield. The regioselective coupling reactions of 1,3,7-trihydroxyxanthone with prenal in the presence of calcium hydroxide at room temperature and under thermal conditions at 140-150 degrees C have been demonstrated to exclusively obtain the natural products osajaxanthone in 75\% yield and nigrolineaxanthone F in 98\% yield, respectively.</p>},
	issn = {0022-3263},
	doi = {10.1021/jo0606655},
	author = {Mondal, Mukulesh and Puranik, Vedavati G. and N. P. Argade}
}
