@article { ISI:000258775400012,
	title = {Novel process for the synthesis of class I antiarrhythmic agent (+/-)-cibenzoline and its analogs},
	journal = {Synthetic Communications},
	volume = {38},
	number = {17},
	year = {2008},
	month = {AUG},
	pages = {2967-2982},
	publisher = {TAYLOR \& FRANCIS INC},
	address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA},
	abstract = {<p>Synthesis of (+/-)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from beta-hydroxynitrile intermediate 2{\textquoteright} followed by the elimination of hydroxyl group respectively. The 2,2-diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (+/-)-2-(2,2-diphenylcyclopropyl)-2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields.</p>},
	keywords = {Benzophenone, cibenzoline, cyclopropanation, diaryl cyanoolefin},
	issn = {0039-7911},
	doi = {10.1080/00397910802006388},
	author = {Gholap, Atul R. and Paul, Vincent and Srinivasan, Kumar V.}
}
