@article { ISI:000254798300018,
	title = {Lipases catalyzed enantioselective hydrolysis of (R,S)-methyl 1,4-benzodioxan-2-carboxylate intermediate for (S)-doxazosin mesylate},
	journal = {World Journal of Microbiology \& Biotechnology},
	volume = {24},
	number = {4},
	year = {2008},
	month = {APR},
	pages = {577-579},
	publisher = {SPRINGER},
	address = {233 SPRING STREET, NEW YORK, NY 10013 USA},
	abstract = {<p>(S)-1,4-benzodioxan-2-carboxylic acid-1 is used as starting compound for the production of the more effective (S) enantiomer of the drug doxazosin mesylate. The catalytic ability of some commercial lipases for preparations of (S) enantiomer of 1 from (+/-) methyl 1,4-benzodioxin-2-carboxylate-2 is reported. Lipases from bacterial sources were more successful in resolving the ester than those from the yeast lipases. About 85\% enantiomerically pure ester was achieved by lipase from alcaligenes sp.</p>},
	keywords = {1, 4-benzodioxan-2-carboxylate, 4-benzodioxan-2-carboxylic acid, doxazosin, Enantioselectivity, Lipases},
	issn = {0959-3993},
	doi = {10.1007/s11274-007-9504-6},
	author = {Varma, Rita and Kasture, Sangita M. and Nene, Sanjay and Kalkote, Uttam R.}
}
