@article { ISI:000267168600002,
	title = {Hydrolytic kinetic resolution as an emerging tool in the synthesis of bioactive molecules},
	journal = {Synlett},
	number = {9},
	year = {2009},
	month = {JUN},
	pages = {1367-1382},
	publisher = {GEORG THIEME VERLAG KG},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>A variety of racemic epoxides mainly derived from terminal olefins, such as aliphatic epoxides, multifuncitonalized epoxides and amine-substituted epoxides, have been successfully resolved into the enantiomerically pure epoxides and diols using Jacobsen{\textquoteright}s hydrolytic kinetic resolution (HKR) method. The chiral epoxides thus prepared were further elaborated by synthetic manipulation to provide a variety Of Compounds of biological interest. A general synthetic strategy for the construction Of S synlanti-1,3-polyol systems using iterative HKR has been developed, which was subsequently utilized in the synthesis of natural products with a broad range of biological activity. The protocol for the 1,3-polyols was also further extended to the synthesis of 1,3-amino alcohols.</p>},
	keywords = {Biological activity, Hydrolytic kinetic resolution, Natural products, synthesis, terminal epoxides},
	issn = {0936-5214},
	doi = {10.1055/s-0029-1217171},
	author = {Kumar, Pradeep and Gupta, Priti}
}
