@article { ISI:000283531100049,
	title = {Probing binding preferences of DNA and RNA: backbone chirality of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids to differentiate DNA versus RNA selective binding},
	journal = {Journal of Organic Chemistry},
	volume = {75},
	number = {21},
	year = {2010},
	month = {NOV},
	pages = {7431-7434},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Subtle differences in RNA and DNA duplex geometry could be sensed by the changed stereochemistry at 3 {\textquoteleft}-amino function in the 5-atom thioacetamido linker of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids modified oligomers. In contrast to the preferred N-type sugar conformations for either 3 {\textquoteleft}- ribo- or xylo amino nucleosides, predominant S-type sugar conformations were found in the dimers. Although the CD spectral differences for the dimer blocks were found to be identical for those found in phosphodiester linked ribo/xylo dimers, the 5-atom thioactamido linker could reverse the RNA binding selectivity to DNA binding selectivity by the change in configuration at the 3 {\textquoteleft}-amino-substituted sugar.</p>},
	issn = {0022-3263},
	doi = {10.1021/jo1014036},
	author = {Gokhale, Sachin S. and Gogoi, Khirud and Kumar, Vaijayanti A.}
}
