@article { ISI:000296752300019,
	title = {Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors},
	journal = {Bioorganic \& Medicinal Chemistry},
	volume = {19},
	number = {23},
	year = {2011},
	month = {DEC},
	pages = {7129-7135},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>We report herein, design and synthesis of vinylaminophosphonates, a novel class of compounds as possible cysteine protease inhibitors. The synthesis of vinylaminophosphonates has been accomplished employing Tsuji-Trost reaction as a key step. The synthesized compounds were assayed against papain, a model cysteine protease and some of our synthesized compounds showed IC50 values in the range of 30-54 mu M thereby suggesting that these chemical entities thus could constitute an interesting template for the design of potential novel protease inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Cysteine, Inhibitor design, Protease inhibitors, synthesis, Tsuji-Trost reaction, Vinylaminophosphonates},
	issn = {0968-0896},
	doi = {10.1016/j.bmc.2011.09.058},
	author = {Bhattacharya, Asish K. and Rana, Kalpeshkumar C.}
}
