@article { ISI:000306049900037,
	title = {Synthesis of the aminocyclitol units of (-)-hygromycin a and methoxyhygromycin from myo-inositol},
	journal = {Journal of Organic Chemistry},
	volume = {77},
	number = {13},
	year = {2012},
	month = {JUL},
	pages = {5801-5807},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Concise and efficient syntheses of the aminocyclitol cores of hygromycin A (HMA) and methoxyhygromycin (MHM) have been achieved starting from readily available myo-inositol. Reductive cleavage of myo-inositol orthoformate to the corresponding 1,3-acetal, stereospecific introduction of the amino group via the azide, and resolution of a racemic cyclitol derivative as its diastereomeric mandelate esters are the key steps in the synthesis. Synthesis of the aminocyclitol core of hygromycin A involved chromatography in half of the total number of steps, and the aminocyclitol core of methoxyhygromycin involved only one chromatography.</p>},
	issn = {0022-3263},
	doi = {10.1021/jo300444b},
	author = {Gurale, Bharat P. and Shashidhar, Mysore S. and Gonnade, Rajesh G.}
}
