@article { ISI:000326008500015,
	title = {Biocatalyst mediated production of 6 beta,11 alpha-dihydroxy derivatives of 4-ene-3-one steroids},
	journal = {Steroids},
	volume = {78},
	number = {11},
	year = {2013},
	month = {NOV},
	pages = {1152-1158},
	publisher = {ELSEVIER SCIENCE INC},
	address = {360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA},
	abstract = {<p>Biotransformation of steroids with 4-ene-3-one functionality such as progesterone (I), testosterone (II), 17 alpha-methyltestosterone (III), 4-androstene-3,17-dione (IV) and 19-nortestosterone (V) were studied by using a fungal system belonging to the genera of Mucor (M881). The fungal system efficiently and quantitatively converted these steroids in regio- and stereo-selective manner into corresponding 6 beta,11 alpha-dihydroxy compounds. Time course experiments suggested that the transformation was initiated by hydroxylation at 6 beta- or 11 alpha-(10 beta-hydroxy in case of V) to form monohydroxy derivatives which upon prolonged incubation were converted into corresponding 613,11oc-dihydroxy derivatives. The fermentation studies carried out using 5 L table-top fermentor with substrates (I and II) clearly indicates that 6 beta,11 alpha-dihydroxy derivatives of steroids with 4-ene-3-one functionality can be produced in large scale by using M881. (C) 2013 Elsevier Ltd.</p>},
	keywords = {4-Ene-3-one steroids, Biotransformation, Mucor sp.},
	issn = {0039-128X},
	doi = {10.1016/j.steroids.2013.08.004},
	author = {Kolet, Swati P. and Niloferjahan, Siddiqui and Haldar, Saikat and Gonnade, Rajesh G. and Thulasiram, Hirekodathakallu V.}
}
