@article { ISI:000336844400011,
	title = {Total synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus flammulina velutipes},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {12},
	number = {24},
	year = {2014},
	month = {APR},
	pages = {4098-4103},
	publisher = {ROYAL SOC CHEMISTRY},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>The first total synthesis of a norsesquiterpene alkaloid (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclo-penta[e]isoindole-1,3(2 H,6H)-dione, isolated from the mushroom-forming fungus Flammulina velutipes, in both racemic and enantiomeric pure forms, is reported. The (-)-enantiomer of the natural product has been synthesized from the D-(-)-pantolactone chiral pool. The synthesis features a one-pot, three-step reaction sequence comprising an enyne RCM/Diels-Alder/aromatization to construct the desired indane skeleton present in the natural product. Our synthesis further confirms the assigned structure and absolute configuration of the natural product.</p>},
	issn = {1477-0520},
	doi = {10.1039/c4ob00300d},
	author = {Kashinath, K. and Jadhav, Prakash D. and Reddy, D. Srinivasa}
}
