@article { ISI:000338042500053,
	title = {Smallest organocatalyst in highly enantioselective direct aldol reaction in wet solvent-free conditions},
	journal = {RSC Advances},
	volume = {4},
	number = {46},
	year = {2014},
	month = {MAY},
	pages = {24311-24315},
	publisher = {ROYAL SOC CHEMISTRY},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>The catalytic efficacy of the smallest organocatalyst, L-proline hydrazide, prepared from a cheaply available natural amino acid, such as L-proline, was studied for the direct asymmetric aldol reaction of various ketones with aromatic aldehydes at room temperature in the presence of several acid additives. A loading of 10 mol\% of catalyst 1 and p-toluenesulphonic acid as an additive was employed in this reaction, and good yields (up to 99\%) with high anti/syn diastereoselectivities (up to 95 : 5) and enantioselectivities (up to \&gt;99.9\%) were achieved in aqueous media.</p>},
	issn = {2046-2069},
	doi = {10.1039/c4ra02690j},
	author = {Bhowmick, Sudipto and Kunte, Sunita S. and Bhowmick, Kartick C.}
}
