@article { ISI:000352546100012,
	title = {Efficient access to enantiopure 1,3-disubstituted isoindolines from selective catalytic fragmentation of an original desymmetrized rigid overbred template},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {13},
	number = {15},
	year = {2015},
	month = {MAR},
	pages = {4438-4448},
	publisher = {ROYAL SOC CHEMISTRY},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>An efficient and scalable synthesis of various enantiopure 1,3-disubstituted isoindolines is reported. The base catalyzed nucleophilic fragmentation of a rigid overbred template is established with various substrates to afford the corresponding 1,3-disubstituted isoindoline ester, amide, thioate, 1,3-amino alcohol and isoindolylcarboxylic acid. The crucial rigid overbred template is synthesized in an optically pure form in multigram scale by asymmetric desymmetrization of the corresponding meso compound.</p>},
	issn = {1477-0520},
	doi = {10.1039/c5ob00229j},
	author = {Pandey, Ganesh and Varkhedkar, Rajesh and Tiwari, Divya}
}
