@article { ISI:000365952200050,
	title = {Ammonium persulfate activated DMSO as a one-carbon synthon for the synthesis of methylenebisamides and other applications},
	journal = {RSC Advances},
	volume = {5},
	number = {123},
	year = {2015},
	month = {NOV},
	pages = {101641-101646},
	publisher = {ROYAL SOC CHEMISTRY},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>Activation of DMSO to work as an economical and environmentally benign one-carbon synthon has been achieved by using a bench-top reagent ammonium persulfate for general and efficient access to symmetrical methylenebisamides from primary amides. This methodology was used to achieve a three-component Mannich reaction using acetophenone, saccharin and DMSO to furnish a beta-amino ketone. It also provided a metal-free synthesis of thiadiazole and bis(phenyl)methane. Effectively, this method uses DMSO as a safer surrogate to formaldehyde. A mechanism for methylenebisamide formation involving radical intermediates has been proposed based on mechanistic studies.</p>},
	issn = {2046-2069},
	doi = {10.1039/c5ra21801b},
	author = {Mahajan, Pankaj S. and Tanpure, Subhash D. and More, Namita A. and Gajbhiye, Jayant M. and Mhaske, Santosh B.}
}
