@article { ISI:000349934600083,
	title = {Proline-catalyzed sequential syn-mannich and [4+1]-annulation cascade reactions to form densely functionalized pyrrolidines},
	journal = {Journal of Organic Chemistry},
	volume = {80},
	number = {3},
	year = {2015},
	month = {FEB},
	pages = {2024-2031},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Coreys sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner.</p>},
	issn = {0022-3263},
	doi = {10.1021/jo5028886},
	author = {Aher, Ravindra D. and Kumar, B. Senthil and Sudalai, Arumugam}
}
