@article { ISI:000364968800017,
	title = {First enantioselective synthesis of surinamensinol B and a non-natural polysphorin analogue by a two-stereocentered hydrolytic kinetic resolution},
	journal = {European Journal of Organic Chemistry},
	volume = {33},
	number = {33},
	year = {2015},
	month = {NOV},
	pages = {7344-7351},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>An efficient and economical approach to the synthesis of antitumor and anti-inflammatory surinamensinol B (1) and antimalarial polysphorin analogue 2 has been achieved with high enantiomeric purity (96\% ee) by starting from commercially available 3,4,5-trimethoxybenzaldehyde. The key steps of the strategy include a Co-catalyzed two-stereocentered hydrolytic kinetic resolution (HKR) of racemic 2[( methoxymethoxy)(3,4,5-trimethoxyphenyl)methyl] oxirane (13) as the chiral inducing step followed by a Mitsunobu reaction. Chiral epoxide 14 and chiral diol 15 were utilized in the syntheses of both compounds.</p>},
	keywords = {Biological activity, Enantioselectivity, Kinetic resolution, Natural products, Total synthesis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201501009},
	author = {Lalwani, Komal G. and Sudalai, Arumugam}
}
