%0 Journal Article %J New Journal of Chemistry %D 2022 %T Synthesis of central spiro-bis-THF fragments of symbiospirols A-C %A Shinde, Mahesh H. %A Kona, Chandrababu N. %A Ramana, V. Chepuri %X

The gold catalysed alkynediol spiroketalization to assemble the central spiro-bis-THF fragments (C22-C33 and C36-C47) of symbiospirols A-C is documented. The adopted chiral pool approach employed commercially available d-glucose and l-malic acid in the synthesis of key building blocks. In addition, two other possible diastereomers have been synthesized in order to establish the relative stereochemistry of the unassigned THF-center of symbiospirols B/C.

%B New Journal of Chemistry %V 46 %P 13738-13744 %8 JUL %G eng %N 28 %9 Article %3

Foreign

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3.925

%R 10.1039/d2nj02227c