%0 Journal Article %J Green Chemistry %D 2019 %T Continuous flow solvent free organic synthesis involving solids (reactants/products) using a screw reactor %A Sharma, Brijesh M. %A Atapalkar, Ranjit S. %A Kulkarni, Amol A. %X

Here we report for the first-time various organic transformations such as aldol condensation, oxidation, nucleophilic substitutions, protection, acylations and coupling reactions using a mechanochemical approach at a controlled temperature using a single synthesis platform. Almost minimal solvents or solvent-free conditions are used, making it a very efficient and clean synthesis of various products. A jacketed screw reactor when operated at different temperatures (0 degrees C to 160 degrees C) and over a range of rotation speeds for changing the residence time (15 s-300 s) helped to achieve maximum conversion. This approach is also extended to the synthesis using substrates having different substitutions, heterocycles and steric hindrance.

%B Green Chemistry %V 21 %P 5639-5646 %8 OCT %G eng %N 20 %9 Article %3

Foreign

%4

9.405

%R 10.1039/c9gc02447f