%0 Journal Article %J Tetrahedron %D 2015 %T Chirality induction and chiron approaches to enantioselective total synthesis of alpha-lipoic acid %A Chavan, Subhash P. %A Pawar, Kailash P. %A Praveen, Ch %A Patil, Niteen B. %K Chiral pool %K Chirality induction %K enantioselective %K Lipoic acid %K sharpless asymmetric dihydroxylation %X

An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R enantiomers of a-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 % overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis. (C) 2015 Elsevier Ltd. All rights reserved.

%B Tetrahedron %V 71 %P 4213-4218 %8 JUN %G eng %N 24 %9 Article %3

Foreign

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2.347

%R 10.1016/j.tet.2015.04.090