%0 Journal Article %J Journal of Organic Chemistry %D 2007 %T Enforcing periodic secondary structures in hybrid peptides: a novel hybrid foldamer containing periodic gamma-turn motifs %A Baruah, Pranjal K. %A Sreedevi, N. K. %A Gonnade, Rajesh G. %A Ravindranathan, Sapna %A Damodaran, Krishnan %A Hofmann, Hans-Joerg %A Sanjayan, Gangadhar J. %K ammonia-TPD %K benzylation reaction %K Ce-Al-MCM-41 %K Friedel-Crafts alkylation %K pyridine-FrIR %X

{This note describes the design, synthesis, and conformational studies of a novel hybrid foldamer that adopts a definite compact, three-dimensional structure determined by a combined effect of the special conformational properties of the foldamer constituents. The striking feature of this de novo designed foldamer is its ability to display periodic gamma-turn conformations stabilized by intramolecular hydrogen bonds. Conformational investigations by single-crystal X-ray studies, solution-state NMR, and ab initio MO theory at the HF/6-31G*

%B Journal of Organic Chemistry %I WILEY-V C H VERLAG GMBH %C PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY %V 72 %P 636-639 %8 JAN %G eng %N 2 %9 Article %3 Foreign %4 4.785 %R 10.1021/jo062032w