%0 Journal Article %J Tetrahedron-Asymmetry %D 2009 %T Concise enantioselective synthesis of (+)-febrifugine %A Emmanuvel, Lourdusamy %A Kamble, Dayanand A. %A Sudalai, Arumugam %X

A short enantioselective synthesis of (+)-febrifugine, a potent antimalarial alkaloid, has been described based on the regioselective asymmetric dihydroxylation of a 1,4-dienic ester as the key step. The strategy also involves chemoselective [3,3]-sigmatropic rearrangement of 1,5-hexadiene-3-ol and intramolecular lactamization of azidolactone for the construction of piperidine core. (C) 2008 Elsevier Ltd. All rights reserved.

%B Tetrahedron-Asymmetry %I PERGAMON-ELSEVIER SCIENCE LTD %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %V 20 %P 84-88 %8 JAN %G eng %N 1 %3 Foreign %4 2.484 %R 10.1016/j.tetasy.2008.11.024