%0 Journal Article %J Bioorganic & Medicinal Chemistry Letters %D 2009 %T Click chemistry based rapid one-pot synthesis and evaluation for protease inhibition of new tetracyclic triazole fused benzodiazepine derivatives %A Mohapatra, Debendra K. %A Maity, Pradip K. %A Shabab, M. %A Khan, Mohammad Islam %X

We describe herein a one-pot synthesis of novel tetracyclic scaffolds that incorporate a fusion of a proline, 1,2,3-triazole ring with [1,4]-benzodiazepin-8(4H)-one ring systems following click chemistry. The expected peptide bond formation followed by in situ 1,3-dipolar cycloaddition in absence of any catalyst led to the formation of new triazole fused benzodiazepine derivatives. (C) 2009 Published by Elsevier Ltd.

%B Bioorganic & Medicinal Chemistry Letters %I PERGAMON-ELSEVIER SCIENCE LTD %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %V 19 %P 5241-5245 %8 SEP %G eng %N 17 %3 Foreign %4 2.661 %R 10.1016/j.bmcl.2009.06.107