%0 Journal Article %J Organic Letters %D 2010 %T Enantioselective synthesis of syn/anti-1,3-amino alcohols via proline-catalyzed sequential alpha-aminoxylation/alpha-amination and horner-wadsworth-emmons olefination of aldehydes %A Jha, Vishwajeet %A Kondekar, Nagendra B. %A Kumar, Pradeep %X

A novel and general method for asymmetric synthesis of both syn/anti-1,3-amino alcohols is described. The method uses proline-catalyzed sequential alpha-aminoxylation/alpha-amination and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes as the key step. By using this method, a short synthesis of a bioactive molecule, (R)-1-((S)-1-methylpyrrolidin-2-yl)-5-phenylpentan-2-ol, is also accomplished.

%B Organic Letters %I AMER CHEMICAL SOC %C 1155 16TH ST, NW, WASHINGTON, DC 20036 USA %V 12 %P 2762-2765 %8 JUN %G eng %N 12 %3 Foreign %4 5.250 %R 10.1021/ol100856u