%0 Journal Article %J Chemical Communications %D 2012 %T Multifaceted folding in a foldamer featuring highly cooperative folds %A Ramesh, Veera V. E. %A Priya, Gowri %A Kotmale, Amol S. %A Gonnade, Rajesh G. %A Rajamohanan, Pattuparambil R. %A Sanjayan, Gangadhar J. %X

Herein, we report on the folding pattern observed in a synthetic peptide featuring two highly mutually dependent, yet strikingly dissimilar, closed networks of hydrogen-bonded rings that work in a cumulative fashion to stabilize the entire folded architecture of the peptide. Structural studies unequivocally suggest that disruption of any one of these mutually-dependent hydrogen-bonded networks is deleterious to the stability of the fully folded conformation of the peptide.

%B Chemical Communications %I ROYAL SOC CHEMISTRY %C THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND %V 48 %P 11205-11207 %8 SEP %G eng %N 91 %3 Foreign %4 6.378 %R 10.1039/c2cc35649j