%0 Journal Article %J Organic Letters %D 2013 %T Diverted total syntheses of potent cell adhesion inhibitor peribysin E analogues %A Handore, Kishor L. %A Reddy, D. Srinivasa %X

Preliminary results from a program aimed at the creation of a focused library of analogues around the natural product peribysin E, a potent biologically active and structurally fascinating molecule, are reported. The total synthesis of (+/-)-peribysin E was accomplished using a short route. Eight new analogues of the natural compound have been accomplished by means of ``diverted total synthesis'' in less than 10 steps. The present effort highlights protecting-group-free total syntheses and the shortest route to access these functionally embellished hydrindanes.

%B Organic Letters %I AMER CHEMICAL SOC %C 1155 16TH ST, NW, WASHINGTON, DC 20036 USA %V 15 %P 1894-1897 %8 APR %G eng %N 8 %3

Foreign

%4 6.324 %R 10.1021/ol400555m