%0 Journal Article %J RSC Advances %D 2014 %T Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study %A Shende, Vaishali S. %A Shingote, Savita K. %A Deshpande, Sudhindra H. %A Kuriakose, Nishamol %A Vanka, Kumar %A Kelkar, Ashutosh A. %X

Asymmetric transfer hydrogenation of various cyclic imines proceeded efficiently with water/methanol co-solvent media in 20 min with excellent yields and enantioselectivities by employing Rh-TsDPEN catalyst and sodium formate as a hydrogen donor. The role of the co-solvent in enhanced productivity of the reaction was investigated by DFT. The mechanism for ATH of the imines has been discussed on the basis of the DFT study.

%B RSC Advances %I ROYAL SOC CHEMISTRY %C THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND %V 4 %P 46351-46356 %8 SEP %G eng %N 86 %9 Article %3 Foreign %4 3.289 %R 10.1039/c4ra07964g