%0 Journal Article %J ACS Applied Materials & Interfaces %D 2014 %T Enhancing cubosome functionality by coating with a single layer of poly-epsilon-lysine %A Deshpande, Sonal %A Venugopal, Edakkal %A Ramagiri, Shobha %A Bellare, Jayesh R. %A Kumaraswamy, Guruswamy %A Singh, Neetu %K bioconjugation %K cubosomes %K drug delivery vehicle %K dual loading %K theranostics %X

We report the preparation and characterization of monoolein cubosomes that can be easily surface modified through adsorption of a single layer of cationic poly-epsilon-lysine. Poly-epsilon-lysine coated cubosomes show remarkable stability in serum solution, are nontoxic and, are readily internalized by HeLa cells. The poly-epsilon-lysine coating provides chemical handles for further bioconjugation of the cubosome surface. We also demonstrate that the initial release rate of a hydrophilic drug, Naproxen sodium, from the cubosomes is retarded with just a single layer of polymer. Interestingly, cubosomes loaded with Naproxen sodium, recently shown to have anticancer properties, cause more apoptosis in HeLa cells when compared to free unencapsulated drug.

%B ACS Applied Materials & Interfaces %I AMER CHEMICAL SOC %C 1155 16TH ST, NW, WASHINGTON, DC 20036 USA %V 6 %P 17126-17133 %8 OCT %G eng %N 19 %9 Article %3

Foreign
 

%4

5.76
 

%R 10.1021/am5047872