%0 Journal Article %J Tetrahedron Letters %D 2014 %T Fungi mediated production and practical purification of (R)-(-)-3-quinuclidinol %A Kolet, Swati P. %A Jadhav, Dipesh D. %A Priyadarshini, Balaraman %A Swarge, Bhagyashree N. %A Thulasiram, Hirekodathakallu V. %K (R)-(-)-3-Quinuclidinol %K Amberlite IR-120 %K Biotransformation %K Ion exchange resin %K Mucor pinformis %X

A fungal system belonging to Mucoraceae family (Mucor piriformis) was explored for the asymmetric reduction of a prochiral ketone, 3-quinuclidinone (I) in an efficient manner to produce an important pharmaceutical precursor (R)-(-)-3-quinuclidinol (II) with similar to 96% enantiomeric excess. The efficiency of the process was improved by developing a cation exchange resin (Amberlite IR-120) which assisted the purification of water soluble metabolite II from fermentation media. (C) 2014 Elsevier Ltd. All rights reserved.

%B Tetrahedron Letters %I PERGAMON-ELSEVIER SCIENCE LTD %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %V 55 %P 5911-5914 %8 OCT %G eng %N 43 %3 Foreign %4 2.68 %R 10.1016/j.tetlet.2014.09.015