TY - JOUR T1 - Convenient and mild protocol for preparation of α –trimethylsilyloxyphosphonates using sulfamic acid and their oxidation to α – ketophosphonates in the presence of N-bromosuccinimide JF - Arkivoc Y1 - 2021 A1 - Mitragotri, Satish A1 - Kulkarni, Makarand A1 - Desai, Uday A1 - Wadagaonkar, Prakash AB - A convenient and mild protocol was developed for the trimethylsilylation of α-hydroxyphosphonates using hexamethyldisilazane as the silylating agent in the presence of sulfamic acid (SA) as a heterogeneous solid acid catalyst in dichloromethane as the reaction medium. The utility of SA as the catalyst for deprotection of α-trimethylsilyloxyphosphonates to parent α-hydroxyphosphonates by making a switch to a protic solvent such as methanol was also demonstrated. Furthermore, the oxidation of α–trimethylsilyloxyphosphonates to corresponding α–ketophosphonates was achieved in excellent yields employing N-bromosuccinimide in the presence of catalytic quantity of AIBN. VL - 2021 U3 - Foreign U4 - 1.140 ER -