TY - JOUR T1 - Enantioselective synthesis of 5,6-dihydroindolizines by N-heterocyclic carbene (NHC)-catalyzed core-structure-inspired strategy of azolium-enolate cascade JF - Organic Letters Y1 - 2021 A1 - Ghosh, Arghya A1 - Shee, Sayan A1 - Barik, Shilpa A1 - Gonnade, Rajesh G. A1 - Biju, Akkattu T. AB - The core-structure motivated design has allowed the enantioselective synthesis of 5,6-dihydroindolizines via N-heterocyclic carbene (NHC) catalysis. The NHC-catalyzed reaction of alpha,beta-unsaturated aldehydes with the suitably substituted pyrrole derivatives proceed via the initial generation of alpha,beta-unsaturated acylazoliums from enals, and enolates from pyrroles and the reaction culminated in an efficient cascade process involving the Michael-aldol-lactonization-decarboxylation sequence to afford the products in reasonable yields and high selectivities. The method is further extended to the construction of spirocyclic 5,6-dihydroindolizines. VL - 23 IS - 13 U3 - Foreign U4 - 6.005 ER -