TY - JOUR T1 - Crystal-to-crystal synthesis of helically ordered polymers of trehalose by topochemical polymerization JF - Angewandte Chemie-International Edition Y1 - 2020 A1 - Hema, Kuntrapakam A1 - Gonnade, Rajesh G. A1 - Sureshan, Kana M. KW - Click reaction KW - helical polymers KW - polysaccharide KW - topochemical reactions KW - trehalose AB -

The synthesis of crystalline helical polymers of trehalose via topochemical azide-alkyne cycloaddition (TAAC) of a trehalose-based monomer is presented. An unsymmetrical trehalose derivative having azide and alkyne crystallizes in two different forms having almost similar packing. Upon heating, both the crystals undergo TAAC reaction to form crystalline polymers. Powder X-ray diffraction (PXRD) studies revealed that the monomers in both the crystals polymerize in a crystal-to-crystal fashion; circular dichroism (CD) studies of the product crystals revealed that the formed polymer is helically ordered. This solvent-free, catalyst-free polymerization method that eliminates the tedious purification of the polymeric product exemplifies the advantage of topochemical polymerization reaction over traditional solution-phase polymerization.

VL - 59 IS - 7 U3 -

Foreign

U4 -

12.959

ER -