TY - JOUR T1 - Manganese-catalyzed alpha-olefination of nitriles with secondary alcohols JF - ACS Catalysis Y1 - 2020 A1 - Yadav, Vinita A1 - Landge, Vinod G. A1 - Subaramanian, Murugan A1 - Balaraman, Ekambaram KW - acceptorless dehydrogenation KW - Alcohol KW - alpha-olefination KW - Hydrogen KW - manganese AB -

An expedient catalytic approach for alpha-olefination of nitriles using secondary alcohols with the liberation of molecular hydrogen and water as the only byproducts is reported. This reaction is catalyzed by a molecularly defined manganese(I) pincer complex and operates in the absence of any hydrogen acceptors. A broad range of substrates including cyclic, acyclic, and benzylic alcohols, as well as various nitrile derivatives, such as arylmethyl and heteroarylmethyl nitriles, are employed in the reaction to provide a diverse range of alpha-vinyl nitriles in good to excellent yields. Mechanistic studies showed that the reaction proceeds via dehydrogenative pathway and the activation of alpha(C-H) bond of the alcohol is the rate-determining step.

VL - 10 IS - 2 U3 -

Foreign

U4 -

12.350

ER -