TY - JOUR T1 - Demystifying a hexuronic acid ligand that recognizes Toxoplasma gondii and blocks its invasion into host cells JF - Organic & Biomolecular Chemistry Y1 - 2019 A1 - Subramani, Balamurugan A1 - Shantamurthy, Chethan D. A1 - Maru, Parag A1 - Belekar, Meenakshi A. A1 - Mardhekar, Sandhya A1 - Shanmugam, Dhanasekaran A1 - Kikkeri, Raghavendra AB -

Toxoplasma gondii is a ubiquitous eukaryotic pathogen responsible for toxoplasmosis in humans and animals. This parasite is an obligate intracellular pathogen and actively invades susceptible host cells, a process which is mediated by specific receptor-ligand interactions. Here, we have identified an unnatural 2,4-disulfated D-glucuronic acid (Di-S-GlcA), a hexuronic acid composed of heparin/ heparan sulfate, as a potential carbohydrate ligand that can selectively bind to T. gondii parasites. More importantly, the gelatin conjugated Di-S-GlcA multivalent probe displayed strong inhibition of parasite entry into host cells. These results open perspective for the future use of Di-S-GlcA epitopes in biomedical applications against toxoplasmosis.

VL - 17 IS - 18 U3 -

Foreign

U4 -

3.490

ER -