TY - JOUR T1 - Concise enantioselective synthesis of (R)-selegiline, (S)-benzphetamine and formal synthesis of (R)-sitagliptin via electrophilic azidation of chiral imide enolates JF - Tetrahedron-Asymmetry Y1 - 2015 A1 - Dey, Soumen A1 - Sudalai, Arumugam AB -

A concise and high yielding enantioselective synthesis of (R)-selegiline, an anti-Parkinson's drug, (S)-benzphetamine, an anti-obesity agent, and (S)-sitagliptin, an anti-diabetic drug has been described starting from commercially available starting materials employing Evans' electrophilic azidation of chiral imide enolates as a key chiral inducing step, which proceeds in a highly diastereoselective manner (>99%). (C) 2014 Elsevier Ltd. All rights reserved.

VL - 26 IS - 1 U3 - Foreign U4 -

2.108

ER -