TY - JOUR T1 - Employing arynes for the generation of aryl anion equivalents and subsequent reaction with aldehydes JF - Journal of Organic Chemistry Y1 - 2018 A1 - Gaykar, Rahul N. A1 - Bhunia, Anup A1 - Biju, Akkattu T. AB -

Arynes are highly reactive intermediates, which are utilized for the electrophilic arylation of various X-H bonds (X = O, N, S etc.). Herein, a new synthetic strategy is demonstrated, where arynes are converted into aryl anion equivalents by treatment with phosphines and a base. The addition of phosphines to arynes form the phosphonium salts, which in the presence of a carbonate base generates the aryl anion equivalent. Subsequent addition of the aryl anions with aldehydes afforded the secondary alcohols.

VL - 83 IS - 18 U3 -

Foreign

U4 -

4.805

ER -