TY - JOUR T1 - Cytotoxic and genotoxic assessment of glycolipid-reduced and -capped gold and silver nanoparticles JF - New Journal of Chemistry Y1 - 2010 A1 - Singh, Sanjay A1 - D'Britto, Virginia A1 - Prabhune, Asmita A1 - Ramana, C. V. A1 - Dhawan, Alok A1 - Bhagavatula L. V. Prasad AB -

A systematic cytotoxic and genotoxic evaluation of glycolipid-conjugated silver and gold nanoparticles is carried out. These glycolipid nanoparticle conjugates are obtained by exploiting the reductive capability of a class of glycolipids called sophorolipids that play the role of capping agent as well. Further, when tested for their cytotoxicity and genotoxicity on HepG2 cells, these nanoparticles are found to be cytocompatible up to 100 mu M metal concentrations. Of the two metallic systems investigated, gold nanoparticles are found to be more cytocompatible than the same concentrations of silver nanoparticles. Similarly, it is also demonstrated that at 100 mu M, silver nanoparticles cause more DNA damage compared to gold nanoparticles of similar concentrations.

PB - ROYAL SOC CHEMISTRY CY - THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND VL - 34 IS - 2 U3 - Foreign U4 - 2.631 ER -