TY - JOUR T1 - Enantioselective synthesis of (+)-alpha-conhydrine and (-)-sedamine by L-proline-catalysed alpha-aminooxylation JF - European Journal of Organic Chemistry Y1 - 2010 A1 - Shaikh, Tanveer Mahamadali A1 - Sudalai, Arumugam KW - alkaloids KW - Amino acids KW - Aminooxylation KW - Enantioselectivity KW - organocatalysis AB -

An efficient organocatalytic approach to the enantioslective synthesis of two important piperidine alkaloids, namely (+)-alpha-conhydrine (98% ee) and (-)-sedamine (95% ee), by L-proline-catalysed alpha-aminooxylation of aldehydes has been developed. The strategy involves an intramolecular cyclization to construct the piperidine core.

PB - WILEY-BLACKWELL CY - COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA IS - 18 U3 - Foreign U4 - 3.206 ER -